Homocysteine, smoking and vascular disease
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چکیده
secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia penumoniae infection. The azithromycin in coronary artery disease: elimination of myocardial infection with Chlamydia (ACADEMIC) study. Circulation 1999; 99: 1540–7. [13] Muhlestein JB, Anderson JL, Carlquist JF et al. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease: primary clinical results of the ACADEMIC study. Circulation 2000; 102: 1755–60. [14] Black PN. Anti-inflammatory effects of macrolide antibiotics. Eur Respir J 1997; 10: 971–2. [15] Martin D, Bursill J, Qui MR, Breit SN, Campbell T. Alternative hypothesis for efficacy of macrolides in acute coronary syndromes. Lancet 1998; 351: 1858–9.
منابع مشابه
Role of Homocysteine in Diseases: A Review
ABSTRACT Cardiovascular disease (CVD) is one of the most important causes of mortality worldwide. Several risk factors have been proposed to be associated with CVD. The main risk factors include family history, smoking, hypertension, history of diabetes, hyperlipidemia and obesity. However, new factors have been recently proposed to be assoc...
متن کاملA Possible Genetic Link between MTHFR Genotype and Smoking Behavior
BACKGROUND Hyperhomocysteinemia is an independent risk factor for stroke and other vascular events. The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. However, MTHFR variants have also been reported to be associate...
متن کاملHomocysteine and atherosclerotic disease: the epidemiologic evidence.
Homocysteine is a sulphur-containing amino acid formed during metabolism by one of two pathways by remethylation and transsulfuration. Altered homocysteine metabolism may be implicated as a factor in atherosclerosis, cerebrovascular disease or peripheral vascular disease. It is postulated that homocysteine may damage endothelial cells or acts as a direct causal factor in the thromboembolic proc...
متن کاملPlasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.
CONTEXT Elevated plasma homocysteine is a known risk factor for atherosclerotic vascular disease, but the strength of the relationship and the interaction of plasma homocysteine with other risk factors are unclear. OBJECTIVE To establish the magnitude of the vascular disease risk associated with an increased plasma homocysteine level and to examine interaction effects between elevated plasma ...
متن کاملHomocysteine in cerebrovascular disease: an independent risk factor for subcortical vascular encephalopathy.
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading to dementia. These results were compared to the homocysteine and vitamin plasma concentrations from patients with cerebral large vessel disease...
متن کاملHomocysteine and stroke.
During the past year epidemiological studies have linked elevated plasma total homocysteine concentrations with an increased risk of ischaemic stroke because of arterial disease. Laboratory studies have further explored the mitogenic effects of total homocysteine on vascular smooth muscle, and cytotoxic and thrombophilic effects on vascular endothelium. Also, a clinical trial has shown that low...
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